We study type 2 immune response in PANCREAs, Colon and lung cancer

What DO we do?

We study the type 2 immune response (immunocytes-TH2, ILC2, M2 macrophages; cytokines-IL-33, IL-4, IL-5, IL-13) and their role in tumor progression and autoimmune diseases and how we can leverage them as a potential drug target to treat diseases. We also study how the intratumor microbiome (bacteria and fungi) evokes type 2 immune response in cancers.

Our Tools

We use genetically engineered mouse model (GEM) of the tumor, human and mouse organoid model, and human patient-derived xenograft (PDXs) along with functional genomics technology, metabolomic tracing, and multiplexed immune profiling.